DMSO-induced changes in the procoagulant and fibrinolytic activity of B16 melanoma cells: influence on lung colony formation.
Publication/Presentation Date
1-1-1988
Abstract
In this study DMSO (dimethylsulphoxide) was used as a tool to test the significance of in vitro modifications of procoagulant and fibrinolytic activity of tumor cells for their in vivo metastatic ability. B16 melanoma cells were chosen as the experimental model. After four days' treatment DMSO increased both the procoagulant and fibrinolytic (plasminogen activator) activity of B16 melanoma cells in a dose-related manner. DMSO treated cells showed significantly greater lung colonizing ability than untreated cells. Our results indicate that DMSO treatment in vitro can modulate procoagulant and fibrinolytic activity and the metastatic ability of B16 melanoma cells; however a direct causal relationship between these in vitro and in vivo effects remains to be established.
Volume
6
Issue
5
First Page
377
Last Page
385
ISSN
0262-0898
Published In/Presented At
Casali, B., Lampugnani, M. G., Riganti, M., Niewiarowska, A., Alessio, G., Mussoni, L., Semeraro, N., & Donati, M. B. (1988). DMSO-induced changes in the procoagulant and fibrinolytic activity of B16 melanoma cells: influence on lung colony formation. Clinical & experimental metastasis, 6(5), 377–385. https://doi.org/10.1007/BF01760573
Disciplines
Medicine and Health Sciences
PubMedID
3378375
Department(s)
Department of Medicine
Document Type
Article