Piecing Together How Peroxiredoxins Maintain Genomic Stability.

Authors

James D West
Trevor J Roston
Joseph B. David MD, Lehigh Valley Health NetworkFollow
Kristin M Allan
Matthew A Loberg

Publication/Presentation Date

11-28-2018

Abstract

Peroxiredoxins, a highly conserved family of thiol oxidoreductases, play a key role in oxidant detoxification by partnering with the thioredoxin system to protect against oxidative stress. In addition to their peroxidase activity, certain types of peroxiredoxins possess other biochemical activities, including assistance in preventing protein aggregation upon exposure to high levels of oxidants (molecular chaperone activity), and the transduction of redox signals to downstream proteins (redox switch activity). Mice lacking the peroxiredoxin Prdx1 exhibit an increased incidence of tumor formation, whereas baker's yeast (

Volume

7

Issue

12

ISSN

2076-3921

Published In/Presented At

West, J. D., Roston, T. J., David, J. B., Allan, K. M., & Loberg, M. A. (2018). Piecing Together How Peroxiredoxins Maintain Genomic Stability. Antioxidants (Basel, Switzerland), 7(12), 177. https://doi.org/10.3390/antiox7120177

Disciplines

Medicine and Health Sciences

PubMedID

30486489

Department(s)

Department of Medicine

Document Type

Article