Prolongation of QT interval and antiarrhythmic action of bepridil.
Publication/Presentation Date
1-1-1985
Abstract
Studies were undertaken with bepridil, a new calcium blocker that prolongs the QT interval, to determine the antiarrhythmic and possible arrhythmogenic properties of this agent. The technique of programmed electrical stimulation was employed to evaluate bepridil in 15 patients with symptomatic ventricular tachycardia (VT). Bepridil prevented VT induction in 7 of 15 patients. Bepridil prolonged the QT and refractoriness and a linear correlation could be demonstrated between the percent change in QTc and refractory period prolongation for the bepridil-protected group. Bepridil in one patient reduced by one the number of stimuli required to induce VT, but no spontaneous arrhythmias were noted. Bepridil thus possesses antiarrhythmic properties with a minimal proarrhythmic effect.
Volume
109
Issue
1
First Page
19
Last Page
27
ISSN
0002-8703
Published In/Presented At
Somberg, J., Torres, V., Flowers, D., Miura, D., Butler, B., & Gottlieb, S. (1985). Prolongation of QT interval and antiarrhythmic action of bepridil. American heart journal, 109(1), 19–27. https://doi.org/10.1016/0002-8703(85)90410-7
Disciplines
Medicine and Health Sciences
PubMedID
3871296
Department(s)
Department of Medicine
Document Type
Article