Intravenous quinidine by intermittent bolus for electrophysiologic studies in patients with ventricular tachycardia.
Publication/Presentation Date
12-1-1984
Abstract
The safety and efficacy of intravenous quinidine gluconate, using intermittent boluses of 80 mg/cc every 5 minutes to a total dose of 800 mg, was evaluated in 61 patients referred for electrophysiologic studies (EPS). Patients were referred because of out-of-hospital cardiac arrest (12), symptomatic ventricular tachycardia (VT) (24), asymptomatic VT (18), syncope of unknown origin (6), and supraventricular arrhythmias (1). Clinical heart failure was present in 74% of patients, with a mean ejection fraction of 45 +/- 3 for all patients. Quinidine prevented VT induction in 78% of patients at a mean dose of 9.6 mg/kg and facilitated VT induction in 7% of patients. Quinidine failed to decrease mean arterial pressure in 14 patients, and in the remaining 47 patients arterial pressure decreased by 16%. Six patients had hemodynamically significant hypotension. Two patients had hypotension severe enough to require saline administration, while four had hypotension not needing fluid replacement. Sixteen percent of patients experienced other side effects. Quinidine can be administered safely by intermittent infusion and is effective in preventing programmed stimulation induction of VT. Carefully monitored, intravenous intermittent bolus administration of quinidine should be utilized more frequently in EPS, since significant adverse side effects are infrequent.
Volume
108
Issue
6
First Page
1437
Last Page
1442
ISSN
0002-8703
Published In/Presented At
Torres, V., Flowers, D., Miura, D., & Somberg, J. (1984). Intravenous quinidine by intermittent bolus for electrophysiologic studies in patients with ventricular tachycardia. American heart journal, 108(6), 1437–1442. https://doi.org/10.1016/0002-8703(84)90689-6
Disciplines
Medicine and Health Sciences
PubMedID
6507239
Department(s)
Department of Medicine
Document Type
Article