Prophylactic tocainide or lidocaine in acute myocardial infarction.
Publication/Presentation Date
3-1-1986
Abstract
Twenty-nine patients with acute myocardial infarction (AMI) were studied in a randomized double-blind trial of intravenous lidocaine and tocainide, followed by either oral tocainide or placebo without regard to previous therapy, for the prophylaxis of arrhythmias associated with acute infarction. No patient had symptomatic ventricular tachycardia or fibrillation, although 1 patient taking lidocaine was withdrawn from therapy because of breakthrough arrhythmias. One patient in each group died from mechanical complications of AMI. Tocainide was administered to 16 patients and lidocaine to 13. Seven of the 13 patients receiving lidocaine had ventricular tachycardia or accelerated idioventricular rhythm, compared with 2 of 16 receiving tocainide (p less than 0.05). Adverse effects were noted in 11 of the 13 patients receiving lidocaine and 6 of the 16 patients receiving tocainide. The infusions used provided therapeutic levels of lidocaine or tocainide and the transition to oral tocainide was accomplished safely with maintenance of therapeutic antiarrhythmic levels. Thus, tocainide appears to be at least as efficacious and may be safer than lidocaine for the prophylaxis of ventricular arrhythmias associated with AMI. The transition to oral tocainide is well tolerated and can be accomplished with minimal difficulty.
Volume
57
Issue
8
First Page
527
Last Page
531
ISSN
0002-9149
Published In/Presented At
Keefe, D. L., Williams, S., Torres, V., Flowers, D., & Somberg, J. C. (1986). Prophylactic tocainide or lidocaine in acute myocardial infarction. The American journal of cardiology, 57(8), 527–531. https://doi.org/10.1016/0002-9149(86)90829-5
Disciplines
Medicine and Health Sciences
PubMedID
3082175
Department(s)
Department of Medicine
Document Type
Article