Comparative acute hemodynamic effects of intravenous sodium nitroprusside and MDL-17,043, a new inotropic drug with vasodilator effects, in refractory congestive heart failure.
Publication/Presentation Date
5-1-1985
Abstract
We compared the acute hemodynamic effects of intravenous nitroprusside (NTP), a pure vasodilator, to those of intravenous MDL-17,043 (MDL), a phosphodiesterase inhibitor with inotropic and vasodilator effects, in 12 patients with chronic refractory congestive heart failure (CHF). Intravenous NTP was infused and titrated to achieve optimal hemodynamic effects, whereas MDL was given intravenously in 0.5 mg/kg increments every 10 to 15 minutes until no further increase occurred in cardiac output or until a maximum cumulative dose of 4.5 mg/kg had been given. Both NTP and MDL reduced pulmonary capillary wedge pressure (27 +/- 5 to 15 +/- 6 and 29 +/- 3 to 15 +/- 7 mm Hg, respectively; both p less than 0.0001), systemic vascular resistance (2173 +/- 1137 to 1118 +/- 306 and 1805 +/- 425 to 956 +/- 235 dynes-sec-cm-5, respectively; both p less than 0.0002), mean arterial pressure (85 +/- 18 to 69 +/- 14 and 83 +/- 15 to 75 +/- 16 mm Hg respectively; both p less than 0.05), and increased cardiac index (1.7 +/- 0.4 to 2.6 +/- 0.4 and 1.8 +/- 0.2 to 3.3 +/- 0.5 L/minute/m2, respectively; both p less than 0.05) without an overall significant change in heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
Volume
109
Issue
5 Pt 1
First Page
1006
Last Page
1012
ISSN
0002-8703
Published In/Presented At
Amin, D. K., Shah, P. K., Hulse, S., & Shellock, F. (1985). Comparative acute hemodynamic effects of intravenous sodium nitroprusside and MDL-17,043, a new inotropic drug with vasodilator effects, in refractory congestive heart failure. American heart journal, 109(5 Pt 1), 1006–1012. https://doi.org/10.1016/0002-8703(85)90242-x
Disciplines
Medicine and Health Sciences
PubMedID
3158182
Department(s)
Department of Medicine
Document Type
Article