Etiology of tetracycline-associated pseudomembranous colitis in hamsters.
Publication/Presentation Date
8-1-1979
Abstract
Tetracyclines were implicated in the 1950s in induction of protracted diarrhea and pseudomembranous colitis. Because the pathogenetic mechanism of these illnesses has been questioned recently, we studied tetracycline in hamster models of antibiotic-associated colitis. Orogastric administration of tetracycline caused diarrhea and death, with evidence of hemorrhagic typhlitis. Filtrates of cecal contents were toxic when inoculated into normal hamsters and cell culture monolayers, and toxicity was neutralized with Clostridium sordellii antitoxin. Tetracycline-resistant C. difficile was cultured from stools of these hamsters, but Staphylococcus aureus was not isolated. The value of tetracycline for treatment or prevention of clindamycin-induced colitis in hamsters was also studied, and it was found that daily orogastric administration of tetracycline was poorly protective against clindamycin-induced colitis.
Volume
16
Issue
2
First Page
167
Last Page
170
ISSN
0066-4804
Published In/Presented At
Toshniwal, R., Fekety, R., & Silva, J., Jr (1979). Etiology of tetracycline-associated pseudomembranous colitis in hamsters. Antimicrobial agents and chemotherapy, 16(2), 167–170. https://doi.org/10.1128/AAC.16.2.167
Disciplines
Medicine and Health Sciences
PubMedID
485127
Department(s)
Department of Medicine
Document Type
Article