Echocardiographic assessment of the effect of an antihypertensive regimen on left ventricular performance.
Publication/Presentation Date
3-1-1979
Abstract
A regimen consisting of chlorthalidone, hydralazine and propranolol would be useful in some hypertensive patients with coronary artery disease or aortic dissection if it could be shown that reflex cardiac stimulation induced by hydralazine is completely neutralized by propranolol. Nine hypertensive patients were treated with chlorthalidone during week 1, chlorthalidone and hydralazine during week 2 and a combination of chlorthalidone, hydralazine and propranolol during week 3. Blood pressure, heart rate, mean velocity of circumferential fiber shortening (VCF) measured echocardiographically and plasma renin activity were measured weekly. This potent three drug regimen reduced mean blood pressure from 142 to 102 mm Hg, and with the third drug, propranolol, heart rate, VCF and plasma renin activity returned to control levels from the greater elevated levels produced by the diuretic drug and hydralazine. In six additional patients VCF (an index of left ventricular contractility) was found to be proportionate to the rate of rise of aortic pressure (dP/dt) or aortic shearing force. This regimen appears safe for use in patients with ischemic heart disease and aortic dissection.
Volume
43
Issue
3
First Page
594
Last Page
599
ISSN
0002-9149
Published In/Presented At
Moyer, J. P., Pittman, A. W., Belasco, R. N., & Woods, J. W. (1979). Echocardiographic assessment of the effect of an antihypertensive regimen on left ventricular performance. The American journal of cardiology, 43(3), 594–599. https://doi.org/10.1016/0002-9149(79)90018-3
Disciplines
Medicine and Health Sciences
PubMedID
420108
Department(s)
Department of Medicine
Document Type
Article