Dissociation between thromboxane generation and metastatic potential in cells from a murine fibrosarcoma. Studies with a selective thromboxane synthase inhibitor.
Publication/Presentation Date
4-15-1987
Abstract
Since the highly metastatic variant M4 of the mFS6 fibrosarcoma has the peculiar feature of generating larger amounts of immunoreactive thromboxane B2 (TxB2) than the non-metastatic variant (M9), we used the thromboxane synthase inhibitor dazmegrel (UK-38,485) in an effort to influence its metastatic potential. TxB2 formation by tumor cells freshly harvested from the primary tumor could be completely inhibited by drug addition in vitro. TxB2 generation was inhibited with a dose-response curve, 2 microM being the lowest dazmegrel concentration giving 100% inhibition. Chronic treatment of tumor-bearing mice with dazmegrel (150 mg/kg b.w. twice daily by gavage) from the day of tumor-cell implantation until killing of the animals caused a more than 10-fold reduction in serum TxB2 formation; TxB2 generation by tumor cells was also significantly depressed. This treatment, however, did not significantly modify either primary tumor weight or metastasis formation. Our data suggest that selective inhibition of thromboxane generation in either blood or tumor cells does not prevent spontaneous metastasis formation in the murine model studied.
Volume
39
Issue
4
First Page
488
Last Page
491
ISSN
0020-7136
Published In/Presented At
Vicenzi, E., Lampugnani, M. G., Bolognese Dalessandro, A. P., Niewiarowska, A., de Gaetano, G., & Donati, M. B. (1987). Dissociation between thromboxane generation and metastatic potential in cells from a murine fibrosarcoma. Studies with a selective thromboxane synthase inhibitor. International journal of cancer, 39(4), 488–491. https://doi.org/10.1002/ijc.2910390414
Disciplines
Medicine and Health Sciences
PubMedID
3557705
Department(s)
Department of Medicine
Document Type
Article