Hyperosmotic mannitol and collateral blood flow to ischemic myocardium.
Publication/Presentation Date
11-1-1989
Abstract
Elevation of extracellular osmolality reduces the extent of myocardial and endothelial cell swelling that accompanies acute ischemia, and the reduction of cell swelling is associated with an increase in collateral blood flow to the ischemic area. However, little is known about the effects of hyperosmolality on the vascular resistance of the collateral coronary vasculature. We compared the effects of hyperosmolar mannitol with those of nitroglycerin and dipyridamole on the vascular resistance of large collateral coronary vessels and of the small arterial vasculature in an isolated heart model of regional ischemia. Elevation of osmolality by mannitol increased collateral blood flow to the ischemic region through at least two mechanisms. First, increasing osmolality resulted in dilation of large arterial conductance vessels, similar to that produced by nitroglycerin. In addition, mannitol produced an effect on the coronary circulation at a microvascular level which, per se or in combination with its effect on larger collateral conductance vessels, increased collateral blood flow to ischemic regions.
Volume
47
Issue
5
First Page
438
Last Page
446
ISSN
0022-4804
Published In/Presented At
Vlahakes, G. J., Giamber, S. R., Rothaus, K. O., & Powell, W. J., Jr (1989). Hyperosmotic mannitol and collateral blood flow to ischemic myocardium. The Journal of surgical research, 47(5), 438–446. https://doi.org/10.1016/0022-4804(89)90098-x
Disciplines
Medicine and Health Sciences
PubMedID
2509818
Department(s)
Department of Medicine
Document Type
Article