Penicillin failure in the treatment of Bacteroides fragilis lung abscess. Experimental study in rabbits.
Publication/Presentation Date
1-1-1983
Abstract
Carbenicillin, chloramphenicol, doxycycline, and clindamycin were compared with penicillin for the treatment of lung abscess in an animal model produced by transtracheal inoculation of a mixture of anaerobes: Bacteroides fragilis, Peptococcus morbillorum, Eubacterium lentum and Fusobacterium nucleatum. Both chloramphenicol and doxycycline eliminated the bacteria but failed to close the abscess cavity. Carbenicillin, although it eradicated B. fragilis, failed to close the abscess cavity in 3 of 6 animals. In all animals tested, clindamycin sterilized the abscess cavities and healed the lung abscesses, while penicillin failed to eradicate the infection. Clindamycin was significantly more effective than penicillin in the elimination of anaerobic bacteria from the lung (p less than 0.05). Clindamycin also closed the abscess cavity faster than penicillin (p less than or equal to 0.02). The superior efficacy of clindamycin may have been the result of accumulation in the lung tissue in concentrations four- to eightfold higher than in the serum.
Volume
29
Issue
4
First Page
289
Last Page
293
ISSN
0009-3157
Published In/Presented At
Thadepalli, H., Kannangara, D. W., & Bach, V. T. (1983). Penicillin failure in the treatment of Bacteroides fragilis lung abscess. Experimental study in rabbits. Chemotherapy, 29(4), 289–293. https://doi.org/10.1159/000238211
Disciplines
Medicine and Health Sciences
PubMedID
6872619
Department(s)
Department of Medicine
Document Type
Article