Chemoprophylaxis of anaerobic pulmonary infections. An experimental study in rabbits.
Publication/Presentation Date
1-1-1982
Abstract
Chemoprophylaxis of anaerobic pulmonary infection due to aspiration was studied in a rabbit model with the view of comparing the efficacy of procaine penicillin, clindamycin, chloramphenicol, doxycycline and cefoxitin. The antibiotic treatment was commenced immediately following transtracheal inoculation of a mixture of Bacteroides fragilis, Streptococcus morbillorum, Fusobacterium nucleatum and Eubacterium lentum. Treatment was stopped after 48 h and lungs were examined for evidence of infection on the 10th day. Only clindamycin and carbencillin were highly efficacious in chemoprophylaxis and both drugs prevented pulmonary infection in 7 of 8 (87%) of the animals tested.
Volume
28
Issue
2
First Page
129
Last Page
134
ISSN
0009-3157
Published In/Presented At
Dhawan, V. K., Thadepalli, H., & Kannangara, D. W. (1982). Chemoprophylaxis of anaerobic pulmonary infections. An experimental study in rabbits. Chemotherapy, 28(2), 129–134. https://doi.org/10.1159/000238067
Disciplines
Medicine and Health Sciences
PubMedID
7075325
Department(s)
Department of Medicine
Document Type
Article