Rod cell-specific antigens in retinoblastoma.
Publication/Presentation Date
7-1-1989
Abstract
We investigated rhodopsin immunoreactivity in five well-differentiated retinoblastomas using a panel of monoclonal antibodies directed against specific antigenic sites in the amino- and carboxyl-terminal portions of rhodopsin. All five monoclonal antibodies bound to the rod cell outer segment of nontumorous retina in all 10% formaldehyde solution-fixed, paraffin-embedded tissue sections. A characteristic "halo" cell surface staining pattern was observed in four (80%) of five tumors treated with two monoclonal antibodies, B6-30 (rhodopsin amino-terminal specific) and K16-107 (rhodopsin carboxyl-terminal specific). In each case, the staining pattern was limited to well-differentiated areas of the tumor containing Flexner-Wintersteiner rosettes or fleurettes. One tumor was not stained by any monoclonal antibody, whereas all monoclonal antibodies stained the rod cell outer segments of nontumorous retina. Our studies indicate that selected retinoblastomas may be differentiated along a rod photoreceptorlike cell lineage.
Volume
107
Issue
7
First Page
1061
Last Page
1063
ISSN
0003-9950
Published In/Presented At
Vrabec, T., Arbizo, V., Adamus, G., McDowell, J. H., Hargrave, P. A., & Donoso, L. A. (1989). Rod cell-specific antigens in retinoblastoma. Archives of ophthalmology (Chicago, Ill. : 1960), 107(7), 1061–1063. https://doi.org/10.1001/archopht.1989.01070020123044
Disciplines
Medicine and Health Sciences
PubMedID
2473730
Department(s)
Department of Medicine
Document Type
Article