Standardized ejection fraction as a parameter of overall ventricular pump function.
Publication/Presentation Date
7-1-2000
Abstract
To evaluate the pump function of the ventricle, a parameter which (i) incorporates systolic and diastolic function and (ii) separates the heart from preload and afterload is needed. This study utilized ejection fraction (EF), calculated from the end-systolic (ES) and end-diastolic (ED) pressure-volume relationship (PVR) using an arbitrary set of loading conditions. Ten isolated canine hearts with a balloon placed inside the left ventricle were used to determine the ESPVR and EDPVR. An end-diastolic volume (EDV) at a pressure of 15 mmHg and an end-systolic volume (ESV) at 70 mmHg were obtained from the EDPVR and ESPVR, respectively. EF was calculated as (EDV-ESV)/EDV. With low-dose (8 microg/min) and high-dose (40 microg/min) dobutamine infusion, the EF increased from 0.25+/-0.16 to 0.33+/-0.13 and 0.57+/-0.08 (p
Volume
64
Issue
7
First Page
510
Last Page
515
ISSN
0047-1828
Published In/Presented At
Morita, S., Kormos, R. L., Astbury, J. C., Shaub, R. D., Kawai, A., & Griffith, B. P. (2000). Standardized ejection fraction as a parameter of overall ventricular pump function. Japanese circulation journal, 64(7), 510–515. https://doi.org/10.1253/jcj.64.510
Disciplines
Medicine and Health Sciences
PubMedID
10929779
Department(s)
Department of Medicine
Document Type
Article