Female gender exacerbates respiratory depression in leptin-deficient obesity.
Publication/Presentation Date
10-15-2001
Abstract
Obese females are less predisposed to sleep-disordered breathing and have higher serum leptin levels than males of comparable body weight. Because leptin is a powerful respiratory stimulant, especially during sleep, we hypothesized that the elevated leptin level is necessary to maintain normal ventilatory control in obese females. We examined ventilatory control during sleep and wakefulness in male and female leptin-deficient obese C57BL/6J-Lep(ob) mice, wild-type C57BL/6J mice with dietary-induced obesity and high serum leptin levels, and normal weight wild-type C57BL/6J mice. Both male and female C57BL/6J-Lep(ob) mice had depressed hypercapnic ventilatory response (HCVR) in comparison with wild-type animals. In comparison with male C57BL/6J-Lep(ob) mice, female C57BL/6J-Lep(ob) mice had reduced HCVR and respiratory drive (a ratio of tidal volume to inspiratory time) both during non-rapid eye movement (NREM) sleep and wakefulness. In contrast, the HCVR did not differ between sexes in wild-type mice during NREM sleep and wakefulness, but was lower in females during REM sleep. Thus, leptin deficiency in female obesity is even more detrimental to hypercapnic ventilatory control during wakefulness and NREM sleep than in obese, leptin-deficient males.
Volume
164
Issue
8 Pt 1
First Page
1470
Last Page
1475
ISSN
1073-449X
Published In/Presented At
Polotsky, V. Y., Wilson, J. A., Smaldone, M. C., Haines, A. S., Hurn, P. D., Tankersley, C. G., Smith, P. L., Schwartz, A. R., & O'Donnell, C. P. (2001). Female gender exacerbates respiratory depression in leptin-deficient obesity. American journal of respiratory and critical care medicine, 164(8 Pt 1), 1470–1475. https://doi.org/10.1164/ajrccm.164.8.2101100
Disciplines
Medicine and Health Sciences
PubMedID
11704598
Department(s)
Department of Surgery
Document Type
Article