New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.
Publication/Presentation Date
1-1-2011
Abstract
Prostate cancer is the most common cancer in men in the United States, and it is the second leading cause of cancer-related death in American men. The androgen receptor (AR), a receptor of nuclear family and a transcription factor, is the most important target in this disease. While most efforts in the clinic are currently directed at lowering levels of androgens that activate AR, resistance to androgen deprivation eventually develops. Most prostate cancer deaths are attributable to this castration-resistant form of prostate cancer (CRPC). Recent work has shed light on the importance of epigenetic events including facilitation of AR signaling by histone-modifying enzymes, posttranslational modifications of AR such as sumoylation. Herein, we provide an overview of the structure of human AR and its key structural domains that can be used as targets to develop novel antiandrogens. We also summarize recent findings about the antiandrogens and the epigenetic factors that modulate the action of AR.
Volume
2011
First Page
918707
Last Page
918707
ISSN
2090-312X
Published In/Presented At
Godbole, A. M., & Njar, V. C. (2011). New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer. Prostate cancer, 2011, 918707. https://doi.org/10.1155/2011/918707
Disciplines
Medicine and Health Sciences
PubMedID
22111003
Department(s)
Department of Medicine
Document Type
Article