Hypothermia for acute ischaemic stroke.
Publication/Presentation Date
3-1-2013
Abstract
Ischaemic stroke is one of the leading causes of death and disability worldwide, and intravenous alteplase is the only proven effective treatment in the acute setting. Hypothermia has been shown to improve neurological outcomes after global ischaemia-hypoxia in comatose patients who have had cardiac arrest, and is one of the most extensively studied and powerful therapeutic strategies in acute ischaemic stroke. The protective mechanisms of therapeutic hypothermia affect the ischaemic cascade across several parallel pathways and, when coupled with reperfusion strategies, might yield synergistic benefits for patients who have had a stroke. Technological advances have allowed hypothermia to be induced rapidly, and the treatment has been used safely in acute stroke patients. Conclusive efficacy trials assessing therapeutic hypothermia combined with reperfusion therapies in acute ischaemic stroke are ongoing.
Volume
12
Issue
3
First Page
275
Last Page
284
ISSN
1474-4465
Published In/Presented At
Wu, T. C., & Grotta, J. C. (2013). Hypothermia for acute ischaemic stroke. The Lancet. Neurology, 12(3), 275–284. https://doi.org/10.1016/S1474-4422(13)70013-9
Disciplines
Medicine and Health Sciences
PubMedID
23415567
Department(s)
Department of Medicine
Document Type
Article