Optimizing prediction scores for poor outcome after intra-arterial therapy in anterior circulation acute ischemic stroke.
Publication/Presentation Date
12-1-2013
Abstract
BACKGROUND AND PURPOSE: Intra-arterial therapy (IAT) promotes recanalization of large artery occlusions in acute ischemic stroke. Despite high recanalization rates, poor clinical outcomes are common. We attempted to optimize a score that combines clinical and imaging variables to more accurately predict poor outcome after IAT in anterior circulation occlusions.
METHODS: Patients with acute ischemic stroke undergoing IAT at University of Texas (UT) Houston for large artery occlusions (middle cerebral artery or internal carotid artery) were reviewed. Independent predictors of poor outcome (modified Rankin Scale, 4-6) were studied. External validation was performed on IAT-treated patients at Emory University.
RESULTS: A total of 163 patients were identified at UT Houston. Independent predictors of poor outcome (P≤0.2) were identified as score variables using sensitivity analysis and logistic regression. Houston Intra-Arterial Therapy 2 (HIAT2) score ranges 0 to 10: age (≤59=0, 60-79=2, ≥80 years=4), glucose (
CONCLUSIONS: The HIAT2 score, which combines clinical and imaging variables, performed better than all previous scores in predicting poor outcome after IAT for anterior circulation large artery occlusions.
Volume
44
Issue
12
First Page
3324
Last Page
3330
ISSN
1524-4628
Published In/Presented At
Sarraj, A., Albright, K., Barreto, A. D., Boehme, A. K., Sitton, C. W., Choi, J., Lutzker, S. L., Sun, C. H., Bibars, W., Nguyen, C. B., Mir, O., Vahidy, F., Wu, T. C., Lopez, G. A., Gonzales, N. R., Edgell, R., Martin-Schild, S., Hallevi, H., Chen, P. R., Dannenbaum, M., … Savitz, S. I. (2013). Optimizing prediction scores for poor outcome after intra-arterial therapy in anterior circulation acute ischemic stroke. Stroke, 44(12), 3324–3330. https://doi.org/10.1161/STROKEAHA.113.001050
Disciplines
Medicine and Health Sciences
PubMedID
23929748
Department(s)
Department of Medicine
Document Type
Article