Fatal tumor thrombosis due to an inferior vena cava leiomyosarcoma in a patient with antiphospholipid antibody syndrome.
Publication/Presentation Date
6-1-2002
Abstract
We describe a patient with antiphospholipid antibody syndrome (APS) who died because of relentless inferior vena cava (IVC) tumor thrombosis due to an unsuspected leiomyosarcoma. Laboratory confirmation for APS was provided by functional identification of a lupus anticoagulant and anticardiolipin IgG and anti-beta2-glycoprotein I IgM antibodies. Although sensitive for detecting vascular obstruction, radiocontrast venography and magnetic resonance imaging and angiography detected the IVC thrombosis but failed to distinguish its malignant nature. Concomitant refractory thrombocytopenia prevented further invasive diagnostic and therapeutic maneuvers for progressive, severe IVC thrombosis unresponsive to aggressive treatment of APS. Deep venous thrombosis refractory to anticoagulant and immunomodulatory therapies in a patient with APS may be due to a concomitant underlying malignancy, such as a leiomyosarcoma, causing vascular obstruction.
Volume
77
Issue
6
First Page
595
Last Page
599
ISSN
0025-6196
Published In/Presented At
Espiritu, J. D., Creer, M. H., Miklos, A. Z., & Bajaj, M. S. (2002). Fatal tumor thrombosis due to an inferior vena cava leiomyosarcoma in a patient with antiphospholipid antibody syndrome. Mayo Clinic proceedings, 77(6), 595–599. https://doi.org/10.4065/77.6.595
Disciplines
Medicine and Health Sciences
PubMedID
12059132
Department(s)
Department of Medicine
Document Type
Article