Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19.
Publication/Presentation Date
7-16-2024
Abstract
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lavage from 45 patients with mild to moderate disease at three phases (acute, recovery, and convalescent) are evaluated over a year. During the acute phase, inflamed and uninflamed phenotypes are characterized by the expression of tissue repair and host defense response molecules. With recovery, inflammatory and fibrogenic mediators decline and clinical symptoms abate. However, at 9 months, quantified radiographic abnormalities resolve in the majority of patients, and yet compared to healthy persons, all showed ongoing activation of cellular repair processes and depression of the renin-kallikrein-kinin, coagulation, and complement systems. This dissociation of prolonged reparative processes from symptom and radiographic resolution suggests that occult ongoing disruption of the lung proteome is underrecognized and may be relevant to recovery from other serious viral pneumonias.
Volume
5
Issue
7
First Page
101642
Last Page
101642
ISSN
2666-3791
Published In/Presented At
Kanth, S. M., Huapaya, J. A., Gairhe, S., Wang, H., Tian, X., Demirkale, C. Y., Hou, C., Ma, J., Kuhns, D. B., Fink, D. L., Malayeri, A., Turkbey, E., Harmon, S. A., Chen, M. Y., Regenold, D., Lynch, N. F., Ramelli, S., Li, W., Krack, J., Kuruppu, J., … COVID-ARC Study Group (2024). Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19. Cell reports. Medicine, 5(7), 101642. https://doi.org/10.1016/j.xcrm.2024.101642
Disciplines
Medicine and Health Sciences
PubMedID
38981485
Department(s)
Department of Medicine
Document Type
Article