Myocarditis in systemic lupus erythematosus diagnosed by
Publication/Presentation Date
1-1-2018
Abstract
OBJECTIVES: Cardiovascular diseaseand heart failure (CHF) are leading causes of death in systemic lupus erythematosus (SLE). The underlying mechanisms for increased CHF in SLE are unclear but myocardial inflammation and lupus myocarditis (LM) may play a role. We propose that
METHODS: This report describes eight patients with presumed LM; five patients were evaluated due to active cardiorespiratory symptoms and three patients were participating in a pilot study to determine the prevalence of subclinical myocarditis in SLE. Clinical characteristics, laboratory and cardiac testing including electrocardiography (ECG), transthoracic echocardiogram (TTE), coronary artery evaluation as well as
RESULTS: Four patients were African American and the others were Hispanic. Half presented with chest pain; 37% had dyspnoea and 25% were asymptomatic. The median SLE Disease Activity Index (SLEDAI-2K) was 5 (2-18) and SLICC Damage Index (SDI) 0.5 (0-5). The median troponin level was 0.08 ng/mL (0-0.9). The most common ECG findings were non-specific ST-T wave abnormalities (n=5). Fifty per cent of the patients had a decreased ejection fraction on TTE and all patients had diffuse myocardial FDG uptake on
CONCLUSION: This case series is the first to describe the use of
Volume
5
Issue
1
First Page
000265
Last Page
000265
ISSN
2053-8790
Published In/Presented At
Perel-Winkler, Alexandra et al. “Myocarditis in systemic lupus erythematosus diagnosed by 18F-fluorodeoxyglucose positron emission tomography.” Lupus science & medicine vol. 5,1 e000265. 12 Jul. 2018, doi:10.1136/lupus-2018-000265
Disciplines
Medicine and Health Sciences
PubMedID
30094040
Department(s)
Department of Medicine
Document Type
Article