Segmental Darier's Disease Treated With Cryotherapy.

Authors

Ngoc Nguyen, Lehigh Valley Health NetworkFollow
Kevin Liu DO, Lehigh Valley Health NetworkFollow
Marvin Sasson MD, Lehigh Valley Health NetworkFollow
Kirsten S. Bellucci MD, Lehigh Valley Health NetworkFollow

Publication/Presentation Date

10-1-2024

Abstract

Darier's disease is characterized by pruritic keratotic papules resulting from dysfunctional keratinocyte adhesion. Segmental Darier's is a rare variant thought to be caused by a post-zygotic somatic mutation. The mainstay of treatment consists of oral and topical retinoids and corticosteroids. Other treatments include topical calcineurin inhibitors, 5-fluorouracil, vitamin D analogs, ablative lasers, and surgical excision in refractory cases. Segmental Darier's may be difficult to recognize and even more challenging to treat. Herein, we present a case of a 45-year-old female with linear segmental Darier's disease who improved significantly following treatment with cryotherapy.

Volume

16

Issue

10

First Page

72068

Last Page

72068

ISSN

2168-8184

Published In/Presented At

Nguyen, N., Liu, K., Sasson, M., & Bellucci, K. (2024). Segmental Darier's Disease Treated With Cryotherapy. Cureus, 16(10), e72068. https://doi.org/10.7759/cureus.72068

Disciplines

Medicine and Health Sciences

PubMedID

39569257

Department(s)

Department of Medicine, Fellows and Residents, Department of Pathology and Laboratory Medicine

Document Type

Article