Segmental Darier's Disease Treated With Cryotherapy.
Abstract
Darier's disease is characterized by pruritic keratotic papules resulting from dysfunctional keratinocyte adhesion. Segmental Darier's is a rare variant thought to be caused by a post-zygotic somatic mutation. The mainstay of treatment consists of oral and topical retinoids and corticosteroids. Other treatments include topical calcineurin inhibitors, 5-fluorouracil, vitamin D analogs, ablative lasers, and surgical excision in refractory cases. Segmental Darier's may be difficult to recognize and even more challenging to treat. Herein, we present a case of a 45-year-old female with linear segmental Darier's disease who improved significantly following treatment with cryotherapy.
This paper has been withdrawn.