Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning.
Publication/Presentation Date
6-1-2016
Abstract
Delayed engraftment and cord graft failure (CGF) are serious complications after unrelated cord blood (UCB) hematopoietic stem cell transplantation (HSCT), particularly when using low-cell-dose UCB units. The haplo-cord HSCT approach allows the use of a lower dose single UCB unit by co-infusion of a CD34(+) selected haploidentical graft, which provides early transient engraftment while awaiting durable UCB engraftment. We describe the frequency, complications, and risk factors of CGF after reduced-intensity conditioning haplo-cord HSCT. Among 107 patients who underwent haplo-cord HSCT, 94 were assessable for CGF, defined as
Volume
22
Issue
6
First Page
1065
Last Page
1072
ISSN
1523-6536
Published In/Presented At
Tsai, S. B., Liu, H., Shore, T., Fan, Y., Bishop, M., Cushing, M. M., Gergis, U., Godley, L., Kline, J., Larson, R. A., Martinez, G., Mayer, S., Odenike, O., Stock, W., Wickrema, A., van Besien, K., & Artz, A. S. (2016). Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22(6), 1065–1072. https://doi.org/10.1016/j.bbmt.2016.02.010
Disciplines
Medicine and Health Sciences
PubMedID
26912055
Department(s)
Department of Medicine, Hematology-Medical Oncology Division, Lehigh Valley Topper Cancer Institute
Document Type
Article