Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival.
Publication/Presentation Date
5-1-2016
Abstract
Umbilical cord blood stem cell transplants are commonly used in adults lacking HLA-identical donors. Delays in hematopoietic recovery contribute to mortality and morbidity. To hasten recovery, we used co-infusion of progenitor cells from a partially matched related donor and from an umbilical cord blood graft (haplo-cord transplant). Here we compared the outcomes of haplo-cord and double-cord transplants. A total of 97 adults underwent reduced intensity conditioning followed by haplo-cord transplant and 193 patients received reduced intensity conditioning followed by double umbilical cord blood transplantation. Patients in the haplo-cord group were more often from minority groups and had more advanced malignancy. Haplo-cord recipients received fludarabine-melphalan-anti-thymocyte globulin. Double umbilical cord blood recipients received fludarabine-cyclophosphamide and low-dose total body irradiation. In a multivariate analysis, haplo-cord had faster neutrophil (HR=1.42, P=0.007) and platelet (HR=2.54, P
Volume
101
Issue
5
First Page
634
Last Page
643
ISSN
1592-8721
Published In/Presented At
van Besien, K., Hari, P., Zhang, M. J., Liu, H. T., Stock, W., Godley, L., Odenike, O., Larson, R., Bishop, M., Wickrema, A., Gergis, U., Mayer, S., Shore, T., Tsai, S., Rhodes, J., Cushing, M. M., Korman, S., & Artz, A. (2016). Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival. Haematologica, 101(5), 634–643. https://doi.org/10.3324/haematol.2015.138594
Disciplines
Medicine and Health Sciences
PubMedID
26869630
Department(s)
Department of Medicine, Hematology-Medical Oncology Division, Lehigh Valley Topper Cancer Institute
Document Type
Article
