Graft-versus-host disease in recipients of male unrelated donor compared with parous female sibling donor transplants.
Publication/Presentation Date
5-8-2018
Abstract
Optimal donor selection is critical for successful allogeneic hematopoietic cell transplantation (HCT). Donor sex and parity are well-established risk factors for graft-versus-host disease (GVHD), with male donors typically associated with lower rates of GVHD. Well-matched unrelated donors (URDs) have also been associated with increased risks of GVHD as compared with matched sibling donors. These observations raise the question of whether male URDs would lead to more (or less) favorable transplant outcomes as compared with parous female sibling donors. We used the Center for International Blood and Marrow Transplant Research registry to complete a retrospective cohort study in adults with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome, who underwent T-cell replete HCT from these 2 donor types (parous female sibling or male URD) between 2000 and 2012. Primary outcomes included grade 2 to 4 acute GVHD (aGVHD), chronic GVHD (cGVHD), and overall survival. Secondary outcomes included disease-free survival, transplant-related mortality, and relapse. In 2813 recipients, patients receiving male URD transplants (n = 1921) had 1.6 times higher risk of grade 2 to 4 aGVHD (
Volume
2
Issue
9
First Page
1022
Last Page
1031
ISSN
2473-9537
Published In/Presented At
Kumar, A. J., Kim, S., Hemmer, M. T., Arora, M., Spellman, S. R., Pidala, J. A., Couriel, D. R., Alousi, A. M., Aljurf, M. D., Cahn, J. Y., Cairo, M. S., Cutler, C. S., Farhan, S., Gergis, U., Hale, G. A., Hashmi, S. K., Inamoto, Y., Kamble, R. T., Kharfan-Dabaja, M. A., MacMillan, M. L., … Loren, A. W. (2018). Graft-versus-host disease in recipients of male unrelated donor compared with parous female sibling donor transplants. Blood advances, 2(9), 1022–1031. https://doi.org/10.1182/bloodadvances.2017013052
Disciplines
Medicine and Health Sciences
PubMedID
29739773
Department(s)
Department of Medicine, Lehigh Valley Topper Cancer Institute
Document Type
Article