Histiocytic Sarcoma Following B-Lymphoblastic Leukemia/Lymphoma.
Publication/Presentation Date
9-9-2019
Abstract
OBJECTIVES: Rare cases of clonally related histiocytic sarcoma (HS) following B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) have been reported to date.
METHODS: We present a patient with HS, which appeared as a breast mass 12 months after the initial diagnosis of B-ALL.
RESULTS: Both HS and the B-ALL shared IGH-MYC and IGK gene rearrangements. Next-generation sequencing and whole-exome sequencing (WES) studies detected 35 common mutations, as well as mutations unique to B-ALL (16) and HS (15), including BRAF D594G. The patient achieved complete remission of B-ALL, but HS failed to respond to many cycles of intensive chemotherapy regimens. A partial response was achieved with sorafenib, a BRAF-targeted therapy.
CONCLUSIONS: To our knowledge, this is the first study to demonstrate by WES that clonally related B-ALL and HS arise through divergent evolution from a common precursor. We present our findings together with a discussion of the previously reported cases of HS in patients with B-ALL.
Volume
152
Issue
4
First Page
486
Last Page
494
ISSN
1943-7722
Published In/Presented At
Geyer, J. T., Yigit, N., Miyaguchi, A., Cheng, S., Casano, J., Mathew, S., Desai, P., Gergis, U., & Tam, W. (2019). Histiocytic Sarcoma Following B-Lymphoblastic Leukemia/Lymphoma. American journal of clinical pathology, 152(4), 486–494. https://doi.org/10.1093/ajcp/aqz056
Disciplines
Medicine and Health Sciences
PubMedID
31172191
Department(s)
Department of Medicine, Lehigh Valley Topper Cancer Institute
Document Type
Article