Collection of Peripheral Blood Progenitor Cells in 1 Day Is Associated with Decreased Donor Toxicity Compared to 2 Days in Unrelated Donors.
Publication/Presentation Date
6-1-2020
Abstract
Peripheral blood stem cells (PBSCs) have been increasingly used for allogeneic hematopoietic cell transplantation instead of bone marrow stem cells. Current National Marrow Donor Program policy recommends 5 days of daily filgrastim, followed by either 1 or 2 days of apheresis for unrelated donors, depending on collection center choice. To date, there are no published studies comparing the differences in donor experience between 1 day and 2 days of apheresis. We examined 22,348 adult unrelated donor collections in 184 centers between 2006 and 2016. Of these 22,348 donors, 20,004 (89.5%) had collection on 1 day, and the other 2344 (9.5%) had collection over 2 days. Information on why donors underwent apheresis in 1 day or 2 days was not available. Donors who underwent apheresis in 1 day were more likely to be male (67% versus 46%; P < .001), younger (age30, 30% versus 22%; P < .001). Successful collection of the requested CD34
Volume
26
Issue
6
First Page
1210
Last Page
1217
ISSN
1523-6536
Published In/Presented At
Hsu, J. W., Shaw, B. E., Kim, S., Logan, B. R., Sees, J. A., Confer, D. L., Pulsipher, M. A., Shah, N., Switzer, G. E., Abidi, M. H., Ahmed, I. A., Anderlini, P. N., Bredeson, C., Chhabra, S., Dandoy, C. E., Diaz, M. A., Farhadfar, N., Ganguly, S., Gergis, U., Hale, G. A., … Wingard, J. R. (2020). Collection of Peripheral Blood Progenitor Cells in 1 Day Is Associated with Decreased Donor Toxicity Compared to 2 Days in Unrelated Donors. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 26(6), 1210–1217. https://doi.org/10.1016/j.bbmt.2020.02.011
Disciplines
Medicine and Health Sciences
PubMedID
32088366
Department(s)
Department of Medicine, Lehigh Valley Topper Cancer Institute
Document Type
Article