Chimeric Antigen Receptor T-cell Therapy for Acute Myeloid Leukemia.
Publication/Presentation Date
12-15-2022
Abstract
Chimeric antigen receptor (CAR) T-cells targeting CD19 have drastically improved the outcomes of B-cell malignancies; however, the success has not yet extended to myeloid malignancies such as acute myeloid leukemia (AML). Main impediments in the development of CAR T therapy in AML include difficulty in identifying appropriate target antigens that are specific to myeloid leukemia stem cells while sparing the healthy hematopoietic stem progenitor cells (HSPCs). Herein, we discuss the current state of CAR T-cell therapy in AML, highlighting recent progress and limitations in clinical translation. We also discuss novel approaches in CAR T therapy development and potential strategies to enhance anti-leukemic activity while minimizing toxicity to heathy cells to make CAR T-cell therapy a viable option for patients with AML.
Volume
15
Issue
3
First Page
131
Last Page
136
ISSN
2589-0646
Published In/Presented At
Bi, X., Hsu, J., Gergis, M., Yang, Y., Yi, D., & Gergis, U. (2022). Chimeric Antigen Receptor T-cell Therapy for Acute Myeloid Leukemia. Hematology/oncology and stem cell therapy, 15(3), 131–136. https://doi.org/10.56875/2589-0646.1062
Disciplines
Medicine and Health Sciences
PubMedID
36537909
Department(s)
Department of Medicine, Lehigh Valley Topper Cancer Institute
Document Type
Article