Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation.
Publication/Presentation Date
10-7-2024
Abstract
Autologous peripheral blood stem cell (PBSC) transplantation is a standard treatment of multiple myeloma (MM), Hodgkin lymphoma and various subtypes of non-Hodgkin lymphoma. Cryopreservation of hematopoietic stem cells is standard practice that allows time for delivery of conditioning regimen prior to cell infusion. The aim of this Worldwide Network for Blood & Marrow Transplantation (WBMT) work was to assess existing evidence on non-cryopreserved autologous transplants through a systematic review/meta-analysis, to study feasibility and safety of this approach. We searched PubMed, Web of Science and SCOPUS for studies that utilized non-cryopreserved autologous PBSC transplantation. Identified literature was reviewed for information on mobilization, apheresis, preservation and viability, conditioning regimen, engraftment, response, and survival. Results highlight collective experience from 19 transplant centers (1686 patients), that performed autologous transplants using non-cryopreserved PBSCs. The mean of infused CD34+ was 5.6 × 10
ISSN
1476-5365
Published In/Presented At
Bekadja, M. A., Niederwiser, D., Kharfan-Dabaja, M. A., El Fakih, R., Garderet, L., Yakoub-Agha, I., Greinix, H., Weisdorf, D. J., Galeano, S., Ahmed, S. O., Chabanon, C., Hashmi, S. K., Ruggeri, A., Gergis, U., Bazarbachi, A., Hamad, N., Albeihany, A., Pasquini, M., Hanbali, A., Szer, J., … Rasheed, W. (2024). Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation. Bone marrow transplantation, 10.1038/s41409-024-02431-y. Advance online publication. https://doi.org/10.1038/s41409-024-02431-y
Disciplines
Medicine and Health Sciences
PubMedID
39375527
Department(s)
Department of Medicine, Lehigh Valley Topper Cancer Institute
Document Type
Article