Thoracic radiotherapy variables: influence on local control in small cell lung cancer limited disease.
Publication/Presentation Date
12-1-1990
Abstract
In limited small cell lung cancer (LSCLC), the high local failure rate of chemotherapy by itself (60-100%) and with the addition of external beam radiotherapy (approximately 30%) has led to investigation of methods to improve local control. To that end, we integrated Platinum 60 mg/m2, d. 1, 22 and Etoposide 120 mg/m2, d. 4, 6, & 8; 25, 27 & 29 with concurrent twice-daily 150 cGy (total dose: 4500 cGy). Of 32 consecutively referred patients, 4 with variant histology, 31 were evaluable for toxicity, response, and survival. Two of 4 variant histology patients responded, and 27 of 27 pure small cell responded, p = 0.005. CT scans were inaccurate at forecasting survival. Of 17/32 patients considered "positive," 59% of these were survivors; of those considered "negative," 47% were survivors, p = N.S. Radiation portals were volumetrically conservative; the supraclavicular fossa was included infrequently and the contralateral hilum not at all. Local failure occurred in only 1/27 patients (4%). All four variant patients failed locally, p = 0.001. With a median follow-up of 43 months, the actuarial disease-free survival remains nearly 50%. Variant histology is more predictive of local control than the physical factors of dose or volume.
Volume
19
Issue
6
First Page
1473
Last Page
1479
ISSN
0360-3016
Published In/Presented At
Turrisi, A. T., 3rd, & Glover, D. J. (1990). Thoracic radiotherapy variables: influence on local control in small cell lung cancer limited disease. International journal of radiation oncology, biology, physics, 19(6), 1473–1479. https://doi.org/10.1016/0360-3016(90)90360-v
Disciplines
Medicine and Health Sciences
PubMedID
2175739
Department(s)
Department of Medicine
Document Type
Article