Radiation and chemotherapy sensitizers and protectors.
Publication/Presentation Date
1-1-1990
Abstract
Radiosensitizers and radioprotectors are part of the chemical modifier approach to cancer therapy whereby the state of the tumor cells and/or normal tissues are modified such that a therapeutic gain is achieved using conventional radiation or chemotherapy. Radiosensitization can be achieved by the use of oxygen-mimetic compounds, agents that alter DNA sensitivity to irradiation, maneuvers that alter DNA repair processes, and manipulation of tissue oxygenation. Standard chemotherapeutic agents such as cisplatin can be utilized in a manner that optimizes the radiosensitization properties. Protection and sensitization can occur by altering the thiol status of the cell. The chemical modifiers field is both developing novel approaches to cancer treatment and increasing the understanding of basic cancer biology.
Volume
10
Issue
3
First Page
225
Last Page
252
ISSN
1040-8428
Published In/Presented At
Coleman, C. N., & Turrisi, A. T. (1990). Radiation and chemotherapy sensitizers and protectors. Critical reviews in oncology/hematology, 10(3), 225–252. https://doi.org/10.1016/1040-8428(90)90033-o
Disciplines
Medicine and Health Sciences
PubMedID
2257086
Department(s)
Department of Medicine
Document Type
Article