Platinum combined with radiation therapy in small cell lung cancer: focusing like a laser beam on crucial issues.
Publication/Presentation Date
6-1-1994
Abstract
The addition of radiotherapy to combination chemotherapy has been shown to improve survival for patients with limited small cell lung cancer (SCLC). Although SCLC is very sensitive to radiotherapy, the impact of radiation may be confounded by interaction among various radiotherapy factors or by the chemotherapeutic agents used in combination. The potential effects of such radiation factors as dose, volume, fractionation, sequence with chemotherapy, and timing (early v late), as well as choice of chemotherapy, therefore must be carefully considered when designing or comparing clinical trials of combined modality therapy for SCLC. The combination of thoracic radiotherapy plus platinum-based chemotherapy currently represents the cornerstone of such combination treatment for SCLC. Many questions remain, however, and it is hoped that new trials will be designed to focus more precisely on unsettled issues.
Volume
21
Issue
3 Suppl 6
First Page
36
Last Page
42
ISSN
0093-7754
Published In/Presented At
Turrisi A. T., 3rd (1994). Platinum combined with radiation therapy in small cell lung cancer: focusing like a laser beam on crucial issues. Seminars in oncology, 21(3 Suppl 6), 36–42.
Disciplines
Medicine and Health Sciences
PubMedID
8052872
Department(s)
Department of Medicine
Document Type
Article