Volume and dose parameters for survival of non-small cell lung cancer patients.
Publication/Presentation Date
7-1-1997
Abstract
BACKGROUND AND PURPOSE: To determine the effect of tumor volume and dose factors derived from 3-D treatment planning dose distributions on survival outcome for non-small cell lung cancer patients.
MATERIALS AND METHODS: Seventy-six consecutive patients diagnosed with medically inoperable or locally advanced, unresectable non-small cell lung cancer planned with 3-D treatment planning between 1986 and 1992 were the subject of this retrospective study. Patient characteristics and dosimetric parameters were analyzed for influence on overall survival and local progression-free survival (LPFS) using univariate and multivariate analysis.
RESULTS: Nodal stage and stage were the most significant factors for overall survival and LPFS duration on both univariate and multivariate analysis. We found a wide range of primary tumor volume sizes for each stage. Patients with tumor volumes(P = 0.047). In an analysis stratifying patients into four groups by tumor volume (200 cm3) and nodes (negative versus positive), patients in the group with no nodal disease and(P = 0.046). No dose factors were statistically significant for longer survival. Longer LPFS was seen for (a) isocenter dose >70 Gy (P = 0.055) for the overall group of patients, (b) within a subgroup with no nodal disease and >73 Gy (P = 0.054), and (c) within a subgroup with no nodal disease and tumor volume73 Gy (P = 0.086).
CONCLUSIONS: Several findings from the volume and dosimetric analysis in this study are noteworthy. Stage was found to be a poor predictor of primary tumor volume size. Also, tumor volume size (<200 >cm3) in conjunction with nodal status (negative nodes) had an impact on survival though there was a mix of stage (I, IIIa, IIIb) in this group of patients. Finally, dose appears to influence local control (LPFS) for the overall group of patients and when tumor volumes aresize.
Volume
44
Issue
1
First Page
23
Last Page
29
ISSN
0167-8140
Published In/Presented At
Martel, M. K., Strawderman, M., Hazuka, M. B., Turrisi, A. T., Fraass, B. A., & Lichter, A. S. (1997). Volume and dose parameters for survival of non-small cell lung cancer patients. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 44(1), 23–29. https://doi.org/10.1016/s0167-8140(97)00081-9
Disciplines
Medicine and Health Sciences
PubMedID
9288853
Department(s)
Department of Medicine
Document Type
Article