Pemetrexed-induced radiation recall dermatitis in a patient with lung adenocarcinoma: case report and literature review.
Publication/Presentation Date
12-1-2016
Abstract
Radiation recall dermatitis (RRD) is an inflammatory reaction in a previously irradiated field subsequent to the administration of pharmacologic or promoting agents. Herein, we describe a 47-year-old man with NSCLC who was treated with radiotherapy and pemetrexed-based chemotherapy three years prior to developing RRD upon resumption of pemetrexed-based chemotherapy. RRD with pemetrexed is rare and consists of five cases reported thus far. Although RRD is a rare phenomenon, it should be considered in any patient with dermatologic reactions that occur at the site of previous exposure to radiation therapy. When severe, RRD can pose a significant, and possibly life-threatening, impediment to the treatment and care of oncology patients. We discuss the time course, natural history, and management of this condition, as well as a connection to internal organ involvement, such as pneumonitis in thoracic oncology patients.
Volume
8
Issue
12
First Page
1589
Last Page
1589
ISSN
2072-1439
Published In/Presented At
Ge, J., Verma, V., Hollander, A., Langer, C., & Simone, C. B., 2nd (2016). Pemetrexed-induced radiation recall dermatitis in a patient with lung adenocarcinoma: case report and literature review. Journal of thoracic disease, 8(12), E1589–E1593. https://doi.org/10.21037/jtd.2016.12.102
Disciplines
Medicine and Health Sciences
PubMedID
28149588
Department(s)
Department of Medicine
Document Type
Article