c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.
Publication/Presentation Date
10-1-2009
Abstract
1,25-Dihydroxyvitamin D3 (1,25D) induces differentiation of myeloid leukemia cells, but resistant cells are also encountered. We studied the mechanistic basis for the resistance in a model system using enhancers of 1,25D, the antioxidant carnosic acid and a kinase inhibitor SB202190. Knock-down (KD) of JNK2p54 unexpectedly increased the intensity of differentiation induced by the 1,25D, carnosic acid and SB202190 (DCS) combination. This was associated with upregulation of activated JNK1p46, and the transcription factors regulated by the JNK pathway, c-Jun, ATF2 and JunB, as well as C/EBP beta. In contrast, KD of JNK1p46 reduced the intensity of DCS-induced differentiation, and partially abrogated activation of c-Jun/AP-1 transcription factors.
Volume
33
Issue
10
First Page
1372
Last Page
1378
ISSN
1873-5835
Published In/Presented At
Chen-Deutsch, X., Garay, E., Zhang, J., Harrison, J. S., & Studzinski, G. P. (2009). c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. Leukemia research, 33(10), 1372–1378. https://doi.org/10.1016/j.leukres.2009.03.003
Disciplines
Medicine and Health Sciences
PubMedID
19339050
Department(s)
Department of Medicine
Document Type
Article