Pulmonary tumor thrombotic microangiopathy presenting as recurrent syncope.
Publication/Presentation Date
1-1-2020
Abstract
Pulmonary tumor thrombotic microangiopathy is a rare condition in which embolization of tumor cells to the pulmonary arterioles causes fibrocellular intimal thickening and activation of the coagulation cascade resulting in pulmonary hypertension and right heart failure. Herein, we highlight a young 35-year-old male with no known past medical history who presented with recurrent syncope and dyspnea, and was found to have severe right heart failure and pulmonary hypertension. He developed sudden clinical deterioration and died after a cardiac arrest. Autopsy revealed poorly differentiated gastric adenocarcinoma and pulmonary tumor thrombotic microangiopathy. New onset severe pulmonary hypertension and right heart failure without any other obvious etiology should encourage the reader to evaluate for pulmonary tumor thrombotic microangiopathy and undergo a diligent search for underlying malignancy. This case highlights recurrent syncope as a rare presentation of this rapidly fatal disease.
Volume
8
First Page
2050313
Last Page
2050313
ISSN
2050-313X
Published In/Presented At
Burciaga Calderoni, C., Moretta, D. T., Merrill-Henry, J., & Giri, P. C. (2020). Pulmonary tumor thrombotic microangiopathy presenting as recurrent syncope. SAGE open medical case reports, 8, 2050313X20969044. https://doi.org/10.1177/2050313X20969044
Disciplines
Medicine and Health Sciences
PubMedID
35154770
Department(s)
Department of Medicine
Document Type
Article
