Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep.

Authors

Dafne Moretta
Demosthenes G Papamatheakis
Daniel P Morris
Paresh C Giri
Quintin Blood
Samuel Murray
Marian Ramzy
Monica Romero
Srilakshmi Vemulakonda
Sidney Lauw
Lawrence D Longo
Lubo Zhang
Sean M Wilson

Publication/Presentation Date

1-1-2019

Abstract

Autonomic innervation of the pulmonary vasculature triggers vasomotor contractility predominately through activation of alpha-adrenergic receptors (α-ARs) in the fetal circulation. Long-term hypoxia (LTH) modulates pulmonary vasoconstriction potentially through upregulation of α

Volume

10

First Page

1032

Last Page

1032

ISSN

1664-042X

Published In/Presented At

Moretta, D., Papamatheakis, D. G., Morris, D. P., Giri, P. C., Blood, Q., Murray, S., Ramzy, M., Romero, M., Vemulakonda, S., Lauw, S., Longo, L. D., Zhang, L., & Wilson, S. M. (2019). Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep. Frontiers in physiology, 10, 1032. https://doi.org/10.3389/fphys.2019.01032

Disciplines

Medicine and Health Sciences

PubMedID

31555139

Department(s)

Department of Medicine

Document Type

Article