Beneficial Cardiac Structural and Functional Adaptations After Lumbosacral Spinal Cord Epidural Stimulation and Task-Specific Interventions: A Pilot Study.
Publication/Presentation Date
1-1-2020
Abstract
Cardiac myocyte atrophy and the resulting decreases to the left ventricular mass and dimensions are well documented in spinal cord injury. Therapeutic interventions that increase preload can increase the chamber size and improve the diastolic filling ratios; however, there are no data describing cardiac adaptation to chronic afterload increases. Research from our center has demonstrated that spinal cord epidural stimulation (scES) can normalize arterial blood pressure, so we decided to investigate the effects of scES on cardiac function using echocardiography. Four individuals with chronic, motor-complete cervical spinal cord injury were implanted with a stimulator over the lumbosacral enlargement. We assessed the cardiac structure and function at the following time points: (a) prior to implantation; (b) after scES targeted to increase systolic blood pressure; (c) after the addition of scES targeted to facilitate voluntary (i.e., with intent) movement of the trunk and lower extremities; and (d) after the addition of scES targeted to facilitate independent, overground standing. We found significant improvements to the cardiac structure (left ventricular mass = 10 ± 2 g,
Volume
14
First Page
554018
Last Page
554018
ISSN
1662-4548
Published In/Presented At
Legg Ditterline, B. E., Wade, S., Ugiliweneza, B., Singam, N. S., Harkema, S. J., Stoddard, M. F., & Hirsch, G. A. (2020). Beneficial Cardiac Structural and Functional Adaptations After Lumbosacral Spinal Cord Epidural Stimulation and Task-Specific Interventions: A Pilot Study. Frontiers in neuroscience, 14, 554018. https://doi.org/10.3389/fnins.2020.554018
Disciplines
Medicine and Health Sciences
PubMedID
33192245
Department(s)
Department of Medicine
Document Type
Article
