Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19.
Publication/Presentation Date
9-1-2022
Abstract
BACKGROUND: Ethnic minorities have higher rates of infection, hospitalization, and death from COVID-19 compared to White Americans.
RESEARCH QUESTION: Is race/ethnicity an independent predictor of lung dysfunction following hospitalization with COVID-19?
STUDY DESIGN: and Methods: Patients hospitalized at the University of Virginia Medical Center with COVID-19 underwent a questionnaire within 30 days following discharge. Those who had persistent respiratory symptoms were invited to complete spirometry, lung volumes, and diffusion capacity of carbon monoxide. 128 completed pulmonary function testing at 6 months.
RESULTS: Impairments in lung function were present in spirometry, lung volumes, and diffusion capacity of carbon monoxide at 6 months. The most prevalent impairments were noted in FVC (24.4%), FEV1 (20.5%), TLC (23.3%), and DLCO (20.8%). When compared between race/ethnicity groups three lung function parameters demonstrated statistically significant difference, including FEV1/FVC (p = 0.021), RV/TLC (p = 0.006) and DLCO % predicted (p = 0.002). The average difference between Hispanic and non-Hispanic Black patients with respect to DLCO % predicted was 13.09 (p = 0.01) and the average difference between non-Hispanic White and non-Hispanic Black patients was 9.46 (p = 0.04). Differences persisted when controlling for age, BMI, smoking status, history of chronic lung disease, ICU admission, treatment with corticosteroids, and socioeconomic status.
INTERPRETATION: Long-term impairments in lung function following COVID-19 are common, occurring in roughly 22% of patients and across all three major domains of lung function. Non-Hispanic Black race/ethnicity was associated with a statistically significant lower DLCO % predicted when compared to non-Hispanic White and Hispanic patients.
Volume
201
First Page
106939
Last Page
106939
ISSN
1532-3064
Published In/Presented At
Konkol, S. B., Ramani, C., Martin, D. N., Harnish-Cruz, C. K., Mietla, K. M., Sessums, R. F., Widere, J. C., & Kadl, A. (2022). Differences in lung function between major race/ethnicity groups following hospitalization with COVID-19. Respiratory medicine, 201, 106939. https://doi.org/10.1016/j.rmed.2022.106939
Disciplines
Medicine and Health Sciences
PubMedID
36029696
Department(s)
Department of Medicine
Document Type
Article
