Chimeric antigen receptor T cell therapy in octogenarians with B cell lymphoma: a real-world US multicenter collaborative study.
Publication/Presentation Date
3-1-2025
Abstract
Older patients with lymphoma are typically underrepresented in clinical trials with chimeric antigen receptor T cell (CAR T) therapy. In this multicenter, observational study we aimed to assess the safety and efficacy of standard CD19 CAR T in patients 80 years of age or older. At total of 88 patients, median age 82 (range, 80-89) years, were included. Diffuse large B cell lymphoma (DLBCL) (N = 60, 68.2%) represented the most common histology. Patients were treated mostly with axicabtagene ciloleucel (N = 41, 46.6%) followed by lisocabtagene maraleucel (N = 25, 28.4%). Cytokine release syndrome (CRS) (any grade) was seen in 68 (77.3%) and 51 (58%) developed immune effector cell-associated neurotoxicity syndrome (ICANS). Incidence of grade 3-4 CRS and ICANS were 7.4% and 31.4%, respectively. For patients with DLBCL/tFL, the 1-year NRM, relapse, PFS, and OS were 11.6%, 40.8%, 47.6%, and 61.2%, respectively. We conclude that CAR T is feasible and effective in patients 80 years or older with B cell lymphomas. These patients must be provided the opportunity to be evaluated for this curative approach.
ISSN
1476-5365
Published In/Presented At
Kharfan-Dabaja, M. A., Mohty, R., Easwar, N., Johnston, P., Iqbal, M., Epperla, N., Yared, J., Ahmed, N., Hamadani, M., Beitinjaneh, A., Narkhede, M., Jagadeesh, D., Ramakrishnan Geethakumari, P., Dholaria, B., Gergis, U., Munoz, J., Sandoval-Sus, J., Locke, F. L., Fein, J., Khurana, A., … Chavez, J. C. (2025). Chimeric antigen receptor T cell therapy in octogenarians with B cell lymphoma: a real-world US multicenter collaborative study. Bone marrow transplantation, 10.1038/s41409-025-02541-1. Advance online publication. https://doi.org/10.1038/s41409-025-02541-1
Disciplines
Medicine and Health Sciences
PubMedID
40025178
Department(s)
Department of Medicine, Lehigh Valley Topper Cancer Institute
Document Type
Article
