Case Report: Concomitant Diagnosis of Plasma Cell Leukemia in Patient With JAK2 Positive Myeloproliferative Neoplasm.
Publication/Presentation Date
1-1-2020
Abstract
Plasma cell dyscrasias and myeloproliferative neoplasms (MPN) are hematologic malignancies arising from two distinct hematopoietic cell lineages. They rarely occur concomitantly. Here, we report a case of a patient with a recent diagnosis of a JAK2 V617F positive MPN who presented with a new diagnosis of plasma cell leukemia. The patient had presented to the hospital with a leukocytosis predominantly comprised of plasma cells, followed by work-up involving peripheral blood flow cytometry, FISH analysis, and bone-marrow biopsy. FISH analysis was suggestive of a common progenitor cell for these distinct hematologic malignancies. To our knowledge, this case represents the second reported instance of a concomitant JAK2 positive MPN with primary plasma cell leukemia.
Volume
10
First Page
1497
Last Page
1497
ISSN
2234-943X
Published In/Presented At
Kurian, C. J., Thomas, C., Houtmann, S., Klumpp, T., & Binder, A. F. (2020). Case Report: Concomitant Diagnosis of Plasma Cell Leukemia in Patient With JAK2 Positive Myeloproliferative Neoplasm. Frontiers in oncology, 10, 1497. https://doi.org/10.3389/fonc.2020.01497
Disciplines
Medicine and Health Sciences
PubMedID
32974181
Department(s)
Department of Medicine
Document Type
Article