MR imaging of pulmonary parenchyma and emboli by paramagnetic and superparamagnetic contrast agents.
Using experimentally induced pulmonary emboli in an animal model, three intravenously administered contrast agents, Gd-DTPA-albumin microspheres (8-15 microns, 0.2 M particles/mg protein, 39-106 micrograms Gd/mg, 50 mg/ml), Gd-DTPA-liposomes (15-30 microns, 130 micrograms/mg lipid, 6 mg Gd/ml) and superparamagnetic ferrosome, (60 nm, 100 mM iron and 20 mg lipid/ml) were examined for MR imaging. Gd-DTPA entrapped in lung capillaries did not enhance the signal intensity of lung parenchyma, but liposomes (5 ml) served as better Gd-DTPA carriers and increased the parenchymal signal intensity by up to a factor of 2.3. However, neither agent improved delineation of pulmonary emboli. Ferrosome decreased the intensity of lung parenchyma, improving detectability of pulmonary emboli by several factors.
Published In/Presented At
Thakur, M. L., Vinitski, S., Mitchell, D. G., Consigny, P. M., Lin, S., DeFulvio, J., & Rifkin, M. (1990). MR imaging of pulmonary parenchyma and emboli by paramagnetic and superparamagnetic contrast agents. Magnetic resonance imaging, 8(5), 625–630. https://doi.org/10.1016/0730-725x(90)90141-n
Medicine and Health Sciences
Department of Obstetrics and Gynecology