Bone mineral density in adolescent females using depot medroxyprogesterone acetate.
Publication/Presentation Date
2-1-2004
Abstract
STUDY OBJECTIVE: To examine bone mineral density (BMD) on a semi-annual basis among control subjects and adolescent females receiving depot medroxyprogesterone acetate (DMPA) injection or oral contraceptives.
DESIGN: Non-randomized prospective study.
SETTING: Teenage pregnancy prevention intervention clinic.
PARTICIPANTS: Adolescent females who were new users of DMPA injection (N=58, age 12-21) or the oral contraceptive pill (N=71, age 11-19) and normal menstruating girls (N=19, age 15-18).
INTERVENTIONS: Baseline and 6-monthly measures of lumbar vertebral BMD using dual-energy X-ray absorptiometry over a 2-year period.
MAIN OUTCOME MEASURES: comparison of percent change on BMD over time between DMPA users, pill users, and normal menstruating girls.
RESULTS: There was no difference on group characteristics at baseline except for the ethnicity between the controls and the DMPA group. There was a statistically significant decrease in BMD between DMPA users and controls at 6 months (-3.02% change, P=0.014) 12 months (-3.38% change, P=0.001) 18 months (-4.81% change, P
CONCLUSION: There is a relationship between DMPA use and a decrease in BMD compared to normal menstruating controls that seems to persist up to 24 months.
Volume
17
Issue
1
First Page
17
Last Page
21
ISSN
1083-3188
Published In/Presented At
Lara-Torre, E., Edwards, C. P., Perlman, S., & Hertweck, S. P. (2004). Bone mineral density in adolescent females using depot medroxyprogesterone acetate. Journal of pediatric and adolescent gynecology, 17(1), 17–21. https://doi.org/10.1016/j.jpag.2003.11.017
Disciplines
Medicine and Health Sciences
PubMedID
15010034
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article