Bone mineral density in adolescent females using depot medroxyprogesterone acetate.

Publication/Presentation Date

2-1-2004

Abstract

STUDY OBJECTIVE: To examine bone mineral density (BMD) on a semi-annual basis among control subjects and adolescent females receiving depot medroxyprogesterone acetate (DMPA) injection or oral contraceptives.

DESIGN: Non-randomized prospective study.

SETTING: Teenage pregnancy prevention intervention clinic.

PARTICIPANTS: Adolescent females who were new users of DMPA injection (N=58, age 12-21) or the oral contraceptive pill (N=71, age 11-19) and normal menstruating girls (N=19, age 15-18).

INTERVENTIONS: Baseline and 6-monthly measures of lumbar vertebral BMD using dual-energy X-ray absorptiometry over a 2-year period.

MAIN OUTCOME MEASURES: comparison of percent change on BMD over time between DMPA users, pill users, and normal menstruating girls.

RESULTS: There was no difference on group characteristics at baseline except for the ethnicity between the controls and the DMPA group. There was a statistically significant decrease in BMD between DMPA users and controls at 6 months (-3.02% change, P=0.014) 12 months (-3.38% change, P=0.001) 18 months (-4.81% change, P

CONCLUSION: There is a relationship between DMPA use and a decrease in BMD compared to normal menstruating controls that seems to persist up to 24 months.

Volume

17

Issue

1

First Page

17

Last Page

21

ISSN

1083-3188

Disciplines

Medicine and Health Sciences

PubMedID

15010034

Department(s)

Department of Obstetrics and Gynecology

Document Type

Article

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