Pregnancy rates after peritoneal ovum-sperm transfer.
Publication/Presentation Date
6-1-1991
Abstract
We present the technique of peritoneal ovum-sperm transfer as an option for treatment in couples with unexplained infertility factors. In 1989 we reported the first successful pregnancy, in the United States, after transferring sperm and oocyte into the peritoneal cavity. We now report the results of a prospective study of this procedure. Twelve women with unexplained infertility underwent 23 cycles of peritoneal ovum-sperm transfer. Ovulation stimulation was achieved with human menopausal gonadotropin. Ultrasonographically directed oocyte recovery was performed by the transvaginal route with the patient under local anesthesia and sedation. After oocyte recovery, 4.5 +/- 0.4 (mean +/- SE) oocytes and 13.3 +/- 1.0 (mean +/- SE) x 10(6) motile spermatozoa were transferred into the pouch of Douglas. Six clinical pregnancies occurred in 23 stimulated cycles for a pregnancy rate of 26% per cycle. This value compares with the overall pregnancy rates of 16% for in vitro fertilization and 27% for gamete intrafallopian transfer reported by the In Vitro Fertilization Registry. Thus these preliminary data suggest that peritoneal ovum-sperm transfer is at least as successful as in vitro fertilization and gamete intrafallopian transfer. Advantages of peritoneal ovum-sperm transfer over gamete intrafallopian transfer include its being an office nonsurgical procedure not necessitating a general anesthetic and decreased cost. Therefore peritoneal ovum-sperm transfer is a reasonable first approach in couples with unexplained infertility.
Volume
164
Issue
6 Pt 1
First Page
1447
Last Page
1449
ISSN
0002-9378
Published In/Presented At
Coulam, C. B., Peters, A. J., Gentry, M., Gentry, W., Critser, E. S., & Critser, J. K. (1991). Pregnancy rates after peritoneal ovum-sperm transfer. American journal of obstetrics and gynecology, 164(6 Pt 1), 1447–1452. https://doi.org/10.1016/0002-9378(91)91423-t
Disciplines
Medicine and Health Sciences
PubMedID
2048591
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article