Monozygotic twinning associated with mechanical assisted hatching.
Publication/Presentation Date
1-1-1999
Abstract
OBJECTIVE: To determine the effect of mechanical assisted hatching on the pregnancy rate (PR).
DESIGN: A retrospective comparative analysis of hatched versus nonhatched consecutive assisted reproductive technology (ART) cycles.
SETTING: A hospital-based ART program.
PATIENT(S): Patients undergoing ART treatment with assisted hatching (1994-1996) were compared with patients who did not have assisted hatching (1990-1993).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Pregnancy rate, multiple PR, and rate of monozygotic twinning.
RESULT(S): With hatching, the clinical PR per ET increased from 25.2% to 37.1% and the multiple PR per ET increased from 6.8% to 13.1%. In the nonhatched series, there were no monozygotic twins compared with eight cases in the hatched series (1.2% per ET).
CONCLUSION(S): Mechanical assisted hatching increases the PR but concomitantly elevates the rate of multiple gestation and multiple gestation of high order. There is a particularly high risk of monozygotic twinning with mechanical hatching.
Volume
71
Issue
1
First Page
144
Last Page
146
ISSN
0015-0282
Published In/Presented At
Hershlag, A., Paine, T., Cooper, G. W., Scholl, G. M., Rawlinson, K., & Kvapil, G. (1999). Monozygotic twinning associated with mechanical assisted hatching. Fertility and sterility, 71(1), 144–146. https://doi.org/10.1016/s0015-0282(98)00402-6
Disciplines
Medicine and Health Sciences
PubMedID
9935131
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article