Thromboembolic diseases in families of women with placental abruption.
Publication/Presentation Date
9-1-2009
Abstract
BACKGROUND: We explored the incidence of thromboembolic disease in relatives of women diagnosed with placental abruption, a condition that may be related to disordered coagulation.
METHODS: Using data from a multicenter, case-control study of placental abruption, we assessed thromboembolic diseases in first-degree male and female relatives of women with and without abruption. The analysis was restricted to biologic parents and full siblings, below 65 years of age, and corrected for familial clustering.
RESULTS: The prevalence of thromboembolic disease was 7.5% in 852 relatives of 212 placental abruption cases and 4.8% in 792 relatives of 206 controls. This increased risk was driven by an association among sisters of abruption probands (odds ratio = 6.8 [95% confidence interval = 1.8-26.0]), and to a lesser extent, among mothers (2.0 [1.0-4.2]). The risk of thromboembolic diseases was similar among the male relatives of placental abruption cases and controls.
CONCLUSIONS: These data suggest that thromboembolic diseases aggregate within female relatives of women with placental abruption.
Volume
20
Issue
5
First Page
733
Last Page
737
ISSN
1531-5487
Published In/Presented At
Peltier, M. R., Ananth, C. V., Oyelese, Y., Vintzileos, A. M., & New Jersey-Placental Abruption Study Investigators (2009). Thromboembolic diseases in families of women with placental abruption. Epidemiology (Cambridge, Mass.), 20(5), 733–737. https://doi.org/10.1097/EDE.0b013e3181aa2d96
Disciplines
Medicine and Health Sciences
PubMedID
19535986
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article