Effect of antagonists vs agonists on in vitro fertilization outcome.
Publication/Presentation Date
1-1-2004
Abstract
PURPOSE: To compare outcome following in vitro fertilization-embryo transfer (IVF-ET) using controlled ovarian hyperstimulation (COH) regimens using either the gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate vs the GnRH antagonist ganirelix.
METHODS: Women needing IVF for conception were randomly assigned to 300 IU of gonadotropins with ganirelix used in the follicular phase when a follicle with a 14 mm average diameter was attained vs a regimen using leuprolide acetate from the mid-luteal phase of the previous cycle.
RESULTS: There were no differences found in clinical, ongoing, delivered pregnancy rates or implantation rates between groups.
CONCLUSIONS: The use of GnRH antagonists do not seem to reduce IVF outcome compared to using GnRH agonists in COH regimens.
Volume
31
Issue
4
First Page
257
Last Page
259
ISSN
0390-6663
Published In/Presented At
Check, M. L., Check, J. H., Choel, J. K., Davies, E., & Kiefer, D. (2004). Effect of antagonists vs agonists on in vitro fertilization outcome. Clinical and experimental obstetrics & gynecology, 31(4), 257–259.
Disciplines
Medicine and Health Sciences
PubMedID
15672958
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article