Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment.
Publication/Presentation Date
1-1-2021
Abstract
INTRODUCTION: To compare the effects of medication-assisted treatment on the placenta in pregnant women with opioid use disorder and uncomplicated pregnancies.
METHODS: This is a case-controlled study of pregnant women utilizing medication-assisted treatment, buprenorphine or methadone, which were matched to healthy uncomplicated controls by gestational age. Placental evaluations and neonatal outcomes were evaluated. Data analysis performed standard statistics and relative risk analysis with a
RESULTS: There were 143 women who met the inclusion criteria: 103 utilizing MAT, 41 buprenorphine and 62 methadone, and 40 uncomplicated matched healthy controls. The incidence of delayed villous maturation was 36% in the medication-assisted group compared with 10% in controls (RR 3.6: 95% CI 1.37-9.43;
CONCLUSION: Medication-exposed pregnancies have a greater incidence of delayed villous maturation, a larger placental size, and a decreased fetoplacental weight ratio compared to the healthy controls. Larger long-term follow-up studies to evaluate outcomes with the presence of delayed villous maturation are needed.
Volume
2021
First Page
2175026
Last Page
2175026
ISSN
2090-2735
Published In/Presented At
Staszewski, C., Herrera, K. M., Kertowidjojo, E., Ly, V., Iovino, N., Garretto, D., Kaplan, C., Persad, M. D., & Garry, D. J. (2021). Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment. Journal of pregnancy, 2021, 2175026. https://doi.org/10.1155/2021/2175026
Disciplines
Medicine and Health Sciences
PubMedID
34659831
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article