Subclinical autoimmune disease and unexplained abortion.
Publication/Presentation Date
10-15-1984
Abstract
Although it seems likely that some patients with unexplained repeated abortions have early or subclinical autoimmune disease, there are no reports on the incidence of autoimmune serologic abnormalities in such patients by use of a series of tests. This diagnosis would suggest a treatable etiology for reproductive loss. We performed 11 serologic autoimmune tests in sera from 14 patients with three or more unexplained abortions (group II) and compared these results to those of 16 control patients with an established diagnosis for repeated abortions (group I). The groups were similar in age, gravidity, number of spontaneous abortions and live births, and in the interval from last abortion to serum sampling. A positive antinuclear antibody test plus at least one other positive test was found in four of 14 (29%) patients in group II (p less than 0.05). The tests that identified all these patients included levels of antinuclear antibody, antibodies to DNA or extractable nuclear antigen, and low levels of complement 3.
Volume
150
Issue
4
First Page
367
Last Page
371
ISSN
0002-9378
Published In/Presented At
FitzSimmons, J., Tunis, S., Jackson, D., Wapner, R. J., & Jackson, L. (1984). Factors related to subsequent reproductive outcome in couples with repeated pregnancy loss. American journal of medical genetics, 18(3), 407–411. https://doi.org/10.1002/ajmg.1320180308
Disciplines
Medicine and Health Sciences
PubMedID
6333181
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article