Mosaicism in chorionic villus sampling: an association with poor perinatal outcome.
Publication/Presentation Date
4-1-1990
Abstract
Prenatal diagnosis by first-trimester chorionic villus sampling was successful in 4319 pregnancies involving 4395 fetuses. Cytogenetic information was obtained by both rapid cytotrophoblastic preparation and monolayer mesenchymal tissue culture. Chromosomal mosaicism was present in 55 of 4319 (1.3%). The abnormal cell line involved the cytotrophoblast in 79.6% of the mosaic specimens. None of the abnormalities found in the cytotrophoblast were confirmed in the fetus when the tissue culture was normal, supporting the belief that the cells of the mesenchymal core more truly reflect the chromosomal constitution of the fetus. However, a significant increase in the perinatal loss rate in the placental mosaic group was noted when compared with the nonmosaics: 16.7 versus 2.7% (P = .0001). These findings suggest that placental mosaicism may be a cause of perinatal loss.
Volume
75
Issue
4
First Page
573
Last Page
577
ISSN
0029-7844
Published In/Presented At
Johnson, A., Wapner, R. J., Davis, G. H., & Jackson, L. G. (1990). Mosaicism in chorionic villus sampling: an association with poor perinatal outcome. Obstetrics and gynecology, 75(4), 573–577.
Disciplines
Medicine and Health Sciences
PubMedID
2314775
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article